Epigenetic regulation of human naïve pluripotency

Presented by Ritu Kumar, Weill Cornell Medical Center In this presentation, we demonstrate Activation-Induced Cytidine Deaminase (AICDA), an enzyme involved in DNA-dementylation, is a novel regulator of both mouse and human naïve pluripotency. Our study identifies AICDA as a novel regulator of naïve pluripotency through its activity on FGF/ERK signaling and DNA-demethylation, which, in future, will help develop strategies to direct human ESCs to a bona-fide naïve state with high efficiency.