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Clinical Phosphoproteomics to Uncover New Therapeutic Strategies
Clinical Phosphoproteomics to Uncover New Therapeutic Strategies
26:22
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Measuring Protein-Turnover with Heavy Isotope Labeling and Complement Reporter Ions
Measuring Protein-Turnover with Heavy Isotope Labeling and Complement Reporter Ions
29:34
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Deep learning tools in PD 3.0 (CHIMERYS and INFERYS) for TMT analysis
Deep learning tools in PD 3.0 (CHIMERYS and INFERYS) for TMT analysis
31:42
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An Automated Sample Preparation Solution for Mass Spectrometry-based Proteomics
The automated platform enables hands-off protein lysis, DNA removal, protein reduction and alkylation, digestion, TMT labeling, pooling and cleanup, and peptide concentration measurement, providing several workflows and companion reagents to perform
18:25
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TMT: A Versatile and Powerful Approach for Characterization of Proteomes
Isobaric labeling TMT experiments with optimal depth and quantitative accuracy for Proteomics.
40:02
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Thermal Proteome Profiling for Functional and Molecular Characterization of Variant Proteins
We propose the use of thermal proteome profiling (TPP) for studying the impact of these disease related sequence variants on a systems wide level. TPP is a bottom up, TMT-based, quantitative mass spectrometry technique for determining the melt curves
30:52
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Modulation of Cysteines upon cellular signalling
In the present talk we will introduce cysteine modifications, various tools for assessing these and various applications were we have used cysteine-specific proteomics to characterize important cysteine residues in key proteins for cellular signallin
37:56
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SimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics
A simplified and cost effective one-pot reaction workflow in a 96-well plate format (SimPLIT), based on a sodium deoxycholate lysis buffer, that minimizes processing steps and demonstrates improved reproducibility compared to alternative approaches.
20:18
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Streamlined TMT protocols to enable low input proteomics of freshly isolated immune cells
An easy to implement, streamlined workflow that enables quantitative proteome profiling from roughly 2 ÎĽg of protein input per experimental condition
37:06
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Enabling a High-throughput Chemo-proteomics Platform for Screening
We have optimized TMT reagent usage with our platform to appropriately balance over- and under-labeling, while reducing reagent associated costs and hands on time associated with aliquoting reagents.
23:39
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Proteogenomic Analysis of Intrahepatic Cholangiocarcinoma
Genomic, transcriptomic, proteomic, phosphoproteomic and microbiomic studies were performed for the clinical tissue samples from Chinese intrahepatic cholangiocarcinoma (iCCA) patients.
23:42
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Applications of TMT-based Quantitation in Unraveling the Protein Targets of Bioactive Compounds
TMT-based thermal proteome profiling (TPP) and provide examples for identifying targets of different classes of compounds.
16:40
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Thermo Fisher Scientific
United States