A high-throughput functional screen reveals human embryonic stem cell self-renewal signals

Presented by Jean Lu, Genomics Research Center, Academia Sinica This study is the first to identify that a CXCL chemokine can bind to and trigger a receptor tyrosine kinase (RTK), IGF-1R. In addition to IGF-1 and insulin, this is also the third ligand of IGF1-R. These findings increase our understanding of signal transduction and stem cell biology.