Advancing pluripotent stem cell technologies for research and therapy of blood diseases

Presented by Igor Slukvin, University of Wisconsin In this presentation, we will share our recent studies in which we identified HE in hPSC cultures and demonstrated the important role of NOTCH and arterial signaling in specification of definitive HE, thus providing an innovative strategy to aid in generating of definitive lymphomyeloid progenitors from hPSCs through enhancing arterial programming of HE. Learn more about our advances in direct blood programming technologies using modified mRNA and the utility of iPSC models for identifying novel factors involved in leukemia stem cell survival.